New positive data for Kisqali combination in advanced breast cancer

New positive data for Kisqali combination in advanced breast cancer

New positive data for Kisqali combination in advanced breast cancer

"MONALEESA-7 is the first clinical trial to have the statistical power to show that ribociclib has clinical benefit specifically for pre- and perimenopausal women with HR-positive, HER2-negative advanced breast cancer", continued Tripathy. "These new therapeutics have not yet been evaluated in a dedicated large, randomized trial as a potential treatment for the 30-40 percent of women with HR-positive, HER2-negative advanced breast cancer who are pre- or perimenopausal". In a recent phase 2, Simon 2-stage trial, researchers found that the drug, abemaciclib, a selective CDK4/6 inhibitor, was effective in eliciting a partial treatment response in HR+/HER2- patients. Neither adapted DFS nor OS differed between the groups in multivariate analyses adjusted for patient and tumor variables and chemotherapy (hazard ratio [HR] for DFS, 0.97; 95% CI: 0.75-1.25; P =.8; HR for OS, 0.98; 95% CI: 0.67-1.42; P =.9). The primary endpoint of the trial was progression-free survival.

OUTLINE: Patients are randomized to 1 of 2 cohorts. Other adverse events included hot flashes, nausea, leukopenia, and joint pain/stiffness. Ribociclib is beneficial for pre- and perimenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer, according to a study presented at the annual San Antonio Breast Cancer Symposium, held from December 5 to 9 in Texas.

Charles Aznavour mourns death of rock legend Johnny Hallyday
By 1962, he had met the woman who would be his wife for years, and remained his friend to the end, singing star Sylvie Vartan. Tributes poured in from the French president's office to North America after the overnight news of his death.

"Longer follow-up is needed to determine whether the trial will meet its secondary end point of overall survival", Tripathy said in a statement.

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